Peptide research profile
MOTS-c
Also known as mitochondrial open reading frame of the 12S rRNA type-c · mots · motsc
Animal and cellular work suggests metabolic signaling effects, but studies measuring naturally circulating MOTS-c in people do not prove that administered MOTS-c is effective or safe.
Very low evidenceNot FDA approved
- Evidence maturity
- Early signal
- Regulatory status
- Not FDA approved
- Recorded outcomes
- 3
- Indexed sources
- 3
- Side-effect records
- 88Named most often: Allergic reaction · Fatigue · Localised histamine response
Educational. Not medical advice.
Summary
A mitochondrial-derived peptide whose therapeutic evidence remains predominantly preclinical.
What is MOTS-c being studied for?
Metabolic signaling and longevity research
How is it thought to work?
Preclinical models propose folate-linked purine-synthesis inhibition, AICAR accumulation, AMPK activation, and skeletal-muscle metabolic effects.
Recorded outcomes
88 side-effect records on MOTS-c
Free account3 graded outcomes and 3 sources for MOTS-c.
Outcome table and every source open with a free account. No card.
Update history
Updated
- Editorial review of the profile and its sources.
- Record last updated in the Senzu database.
- Profile first published.