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Peptide research profile

Retatrutide

Also known as LY3437943 · reta

A randomized phase 2 trial in 338 adults showed dose-dependent weight reduction over 48 weeks. Phase 3 development is intended to determine whether the benefits, risks, and durability hold in larger populations.

Moderate evidenceInvestigational
Evidence maturity
Developing record
Regulatory status
Investigational
Recorded outcomes
3
Indexed sources
2
Educational information—not medical advice.

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Summary

An investigational triple-receptor agonist with promising phase 2 weight-loss results but no FDA approval.

What is Retatrutide being studied for?

Investigational weight-management therapy

How is it thought to work?

Activates GIP, GLP-1, and glucagon receptors, combining appetite and metabolic signaling pathways.

Recorded outcomes

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3 graded outcomes and 2 sources for Retatrutide.

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Update history

  • Editorial review of the profile and its sources.
  • Record last updated in the Senzu database.
  • Profile first published.
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